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One or more keywords matched the following properties of Gangula, Pandu
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overview As background, my earlier training was as a post-doctoral fellow and Assistant Professor (non T-T) in the Department of Ob/Gyn (1994-2004) and Assistant Professor (T-T) in the Division of Gastroenterology (2004-2008) at UTMB in Galveston, TX. When I arrived in Nashville (2008), my appointment was as an Associate Professor (T-T) in the Department of Ob/Gyn at Meharry; I was also a member of the center for women’s health research (CWHR). In 2012, I was given an appointment in the School of Dentistry and the title of Chair, Oral Biology and Research (70% time/effort). Since then, I organized a SOD course on “Introduction to Clinical Research” and continue to foster collaborative faculty and student research projects. Recently, in Fall 2013 we have introduced “Biomedical Integration Seminar Course” to Freshman Dental Students. This course will allow the students not only to learn how to integrate basic sciences into their dental clinical approach and patient care but also will help them to understand on how poor oral health can cause systemic diseases. For the past several years, I have been providing research training to post-doctoral fellows, research technicians, and junior faculty, and residents, medical and dental students. Dr. Gangula’s research efforts and published work over the years have focused on understanding the role and regulation of nitric oxide, vascular neuropeptides by sex steroid hormones as well as vitamin D in regulating gut motility and vascular functions in both diabetes mellitus and hypertension rodent(s) models as well as in clinical setting. Dr. Gangula have several years of research experience in the field of cardiovascular biology, gastroenterology, endocrinology, fetal programming and female hormone research as evidenced by number of publications (review in PubMed, author name: Gangula P). Recently, Dr. Gangula established research in the area of oral pathogens and its impact on systemic health (cardiovascular and gastrointestinal function). Dr. Gangula was specifically recruited in the division of gastroenterology when he was in UTMB, Galveston, Texas (2004-2008) to investigate the gender bias in gastroparesis and examine the role of female sex steroid hormones, estradiol-17ß (E2) and progesterone (P4) on gut motility functions in both health and disease state. As an Assistant Professor (Non-Tenure-Track; 2000-2004) in UTMB, Galveston, TX, Dr. Gangula served as an active collaborator (co-investigator) for two independent RO1 grants with the collaboration of two separate investigators in the field of endocrinology/physiology. During the past few years, he has been working in the field of gastrointestinal motility disorders associated with diabetic & idiopathic gastroparesis [(delayed gastric emptying) which is a disorder that predominantly affects women)] and IBD. As a primary and corresponding author, he has published several articles in the field of “fetal programming, hypertension and gastroparesis”. Also, As a PI, Dr. Gangula had a grant support from NIIDDK (R21) and Diabetic Research Training Center (DRTC) pilot grant (NIDDK) to investigate the role of oxidative stress and nitric oxide in diabetic gastroparesis. He is a member of the American Gastroenterological Association (AGA), American Neurogastroenterology & Motility Society (ANMS) and the Society for Gynecological Investigations (SG1). Dr. Gangula has trained several post-doctoral fellows, graduate students, technicians, medical and dental students since 2001. He is a member of editorial board for several peer reviewed journals. In addition, he has been serving as a reviewer for several journals including but not limited to American Journal of Physiology and Neurogastroenterology and Motility.
One or more keywords matched the following items that are connected to Gangula, Pandu
Item TypeName
Grant Nitric Oxide and gastric motility in female diabetics
Grant ROLE OF NRF2 IN NITRERGIC MEDIAITED STOMACH MOTILITY
Academic Article Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.
Academic Article Sepiapterin reverses the changes in gastric nNOS dimerization and function in diabetic gastroparesis.
Academic Article Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice.
Academic Article Gender bias in gastroparesis: is nitric oxide the answer?
Academic Article Chronic estrogen deficiency causes gastroparesis by altering neuronal nitric oxide synthase function.
Academic Article Impairment of gastric nitrergic and NRF2 system in apolipoprotein E knockout mice.
Academic Article Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/nNOS/NRF2-Phase II Enzyme Expression.
Academic Article Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers.
Academic Article Effects of Diabetes on Salivary Gland Protein Expression of Tetrahydrobiopterin and Nitric Oxide Synthesis and Function.
Academic Article Role of oral and gut microbiome in nitric oxide-mediated colon motility.
Academic Article Sepiapterin alleviates impaired gastric nNOS function in spontaneous diabetic female rodents through NRF2 mRNA turnover and miRNA biogenesis pathway.
Academic Article Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice.
Academic Article Growth and fertility rates in the offspring of pregnant rats treated with L-omega nitro-L-arginine methyl ester (L-NAME), a nitric oxide inhibitor.
Academic Article Adrenomedullin requires an intact nitric oxide system to function as an endogenous vasodilator in rat gestation.
Academic Article Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum.
Concept Nitric Oxide
Concept Nitric Oxide Synthase
Concept Nitric Oxide Synthase Type I
Concept Nitric Oxide Synthase Type III
Academic Article Nitric oxide donor alleviates ovariectomy-induced bone loss.
Academic Article Porphyromonas gingivalis infection alters Nrf2-phase II enzymes and nitric oxide in primary human aortic endothelial cells.
Academic Article Role of sex hormones and their receptors on gastric Nrf2 and neuronal nitric oxide synthase function in an experimental hyperglycemia model.
Academic Article Inhibition of GSK-3? restores delayed gastric emptying in obesity-induced diabetic female mice.
Academic Article Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice.
Academic Article Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function.
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  • Nitric Oxide
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